Potential of Natural Antioxidants for Upregulating Apoptosis in Cervical Cancer Cells: A Cellular and Molecular Study

Natural antioxidants (NAs) are promising substances, which established as potent therapeutic agents. However, the anticancer potential of many them is not completely known. In this research, effect three natural including geraniol (Ge), citronellol (Cit), and quercetin (Qu), their combination by estimating cytotoxicity on Hela cells at doses from 15.625 to 1000 µg/mL was investigated. Moreover, cisplatin (Cis) employed a strong competitive comparison. After IC50 value each treatment in MTT assay, western blot performed with obtained for further evaluation. regard, expressions caspase3, Bax, Bcl2, p53 proteins were examined. Our results showed that these substances had significant cytotoxic upregulating all mentioned proteins, demonstrated apoptosis pathway. findings also same both Cis-receiving non-Cis-receiving regarding some indices. Consequently, it suggested investigate main or adjuvant therapies side-effect reduction vivo. Overall, can be concluded effective against cancer